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Retatrutide (GLP-3)

Price range: $80.00 through $150.00 Save 11%

In Stock≥ 99% purity10 / 20mgLyophilized

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  • 3+5% off$76.00 each
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For research use only. Not for human or animal consumption. Not evaluated by the FDA.

Common questions

Yes. Reta is the common shorthand for retatrutide, and you will also see it written as GLP-3, GLP3 or Reta 3. They all refer to the same compound, LY3437943 (CAS 2381089-83-2), the triple-receptor agonist listed on this page.

Right here. Lumen Research sells GLP-3 retatrutide for research use in 10mg and 20mg vials, shipped from San Antonio, Texas. Orders placed before 12PM ET ship the same business day, Monday through Saturday, and US orders over $200 ship free.

Yes. Every lot is third-party tested by Freedom Diagnostics (USA), with identity confirmed by LC-MS: the two 10mg lots at 99.76% (lot 590B4F2) and 99.91% (lot RT10-2610) and the 20mg lot at 99.91%, all HPLC-UV purity. Each full Certificate of Analysis is further down this page.

"GLP-3" is an informal nickname rather than a formal classification. Retatrutide acts on three receptors — GLP-1, GIP and glucagon — where tirzepatide acts on two, so the research community started calling it the next step along from GLP-1. The compound's actual designation is LY3437943.

Tirzepatide is a dual GIP/GLP-1 receptor agonist. Retatrutide adds glucagon-receptor activity to those two. We keep a side-by-side write-up of what the published research examined for each in our tirzepatide vs retatrutide comparison.

Its receptor pharmacology was characterised in Coskun et al., Cell Metabolism 2022, and it was examined in Phase 2 trials in adults with obesity (Jastreboff et al., NEJM 2023) and with type 2 diabetes (Rosenstock et al., Lancet 2023), followed by Phase 3 trials published in 2026 (TRIUMPH-1, NEJM; TRIUMPH-2, Lancet). Gastrointestinal events were the most commonly reported adverse findings. Our retatrutide research guide summarizes what each study measured.

Both vials contain the same compound and differ only in the quantity of lyophilized powder. The 20mg vial is the lower cost per milligram. The two sizes come from separately tested lots, so the purity figure for each is in the lab-testing answer above and on its own certificate below.

Credit and debit card, Apple Pay, Google Pay, Zelle and Cash App. Choosing the card option places the order first, then gives you a secure payment link on your order confirmation and in your order email; that link also accepts Apple Pay and Google Pay. Zelle orders receive a 5% discount, applied automatically at checkout.

Orders placed before 12:00 PM ET on a business day are dispatched the same day, Monday through Saturday. Standard US shipping is a $15 flat rate and orders over $200 ship free. Inside San Antonio we also deliver to your door in the evening, or you can meet us and collect free of charge.

Lyophilized powder keeps at −20 °C for long-term storage or 2–8 °C short-term. Once reconstituted with bacteriostatic water, refrigerate at 2–8 °C and keep it out of light. Our reconstitution guide covers the full process.

What the research says about Retatrutide (GLP-3)What published studies have examined, what they found, and the adverse findings on record. Written from cited sources.
🛡️Lab-verified purity: 99.76% to 99.91% by lot · Third-party tested (HPLC-UV & LC-MS) · View Certificate of Analysis ↓

Retatrutide (GLP-3), Triple Receptor Agonist Peptide

Retatrutide is a synthetic 39–amino acid peptide studied in metabolic research as a triple agonist of the GIP, GLP-1, and glucagon receptors. It has become a frequent subject of preclinical and laboratory investigation into receptor-signaling and energy-metabolism pathways. Lumen Research supplies Retatrutide as a high-purity lyophilized powder intended exclusively for in-vitro research and laboratory study.

About Retatrutide

Retatrutide (also referenced in research as GLP-3 or LY3437943) is engineered to interact simultaneously with three incretin and metabolic receptors, making it a notable tool compound in laboratory studies of multi-receptor signaling. Published research is indexed in the peer-reviewed scientific literature.

Retatrutide Research Applications

In laboratory and preclinical settings, this peptide is studied across several areas of interest:

  • Metabolic & energy-expenditure research: examined in models of energy balance and metabolism.
  • GLP-1 receptor signaling: investigated for incretin-pathway activity in research models.
  • GIP receptor signaling: studied alongside GLP-1 pathways in receptor-interaction research.
  • Glucagon receptor signaling: explored for its role in the triple-agonist mechanism.

These describe areas of ongoing scientific investigation only, this compound is not a therapeutic product and no clinical outcomes are implied.

Specifications

Compound Retatrutide (GLP-3 / LY3437943)
Class GIP / GLP-1 / glucagon triple receptor agonist (39 amino acids)
Molecular formula C221H342N46O68
Molecular weight ~4731.3 g/mol
CAS number 2381089-83-2
Form Lyophilized powder

Reconstitution, Storage & Handling

Supplied as a lyophilized powder, the peptide is typically reconstituted with bacteriostatic or sterile water for laboratory use. Store the sealed lyophilized vial at -20 °C, protected from light and moisture, for long-term stability. After reconstitution, store at 2–8 °C and use within the timeframe defined by your laboratory protocol. Handle using standard laboratory safety practices.

For Research Use Only

This product is intended strictly for laboratory and in-vitro research. It is not for human or veterinary use, consumption, or diagnostic application and is not a drug, food, or cosmetic. By purchasing, the buyer affirms they are a qualified researcher or institution. Browse our full catalog of research peptides.

Further reading: Retatrutide research guide, what the studies show.

Retatrutide Certificate of Analysis (COA), Third-Party Lab-Tested

Every lot is independently tested by Freedom Diagnostics (USA). The lots below are verified at 99.76% to 99.91% HPLC-UV purity, with identity confirmed by LC-MS. Each lot has its own Certificate of Analysis.

Size Lot Purity (HPLC-UV) Net content Reported Certificate
10 mg 590B4F2 99.76% 10.95 mg 21 Jun 2026 Retatrutide 10 mg certificate of analysis, lot 590B4F2, 99.76% HPLC-UV purityPDF
10 mg RT10-2610 99.91% 11.51 mg 2 Nov 2026 Retatrutide 10 mg certificate of analysis, lot RT10-2610, 99.91% HPLC-UV purityPDF
20 mg RT20-2610 99.91% 23.97 mg 2 Nov 2026 Retatrutide 20 mg certificate of analysis, lot RT20-2610, 99.91% HPLC-UV purityPDF

Identity confirmed by LC-MS on every lot. Results are specific to the sample tested.

For research use only. Not approved for human or veterinary use, diagnostic, therapeutic, or clinical applications.

2 reviews for Retatrutide (GLP-3)

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  1. Tracy Sabbarese (verified owner) –

  2. Tara K. (verified owner) –

    Amazing product, pure. Not only is the product great but the customer service team is amazing.

    Reviewer received an unconditional discount coupon on future purchases
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