Retatrutide (GLP-3), Triple Receptor Agonist Peptide
Retatrutide is a synthetic 39–amino acid peptide studied in metabolic research as a triple agonist of the GIP, GLP-1, and glucagon receptors. It has become a frequent subject of preclinical and laboratory investigation into receptor-signaling and energy-metabolism pathways. Lumen Research supplies Retatrutide as a high-purity lyophilized powder intended exclusively for in-vitro research and laboratory study.
About Retatrutide
Retatrutide (also referenced in research as GLP-3 or LY3437943) is engineered to interact simultaneously with three incretin and metabolic receptors, making it a notable tool compound in laboratory studies of multi-receptor signaling. Published research is indexed in the peer-reviewed scientific literature.
Retatrutide Research Applications
In laboratory and preclinical settings, this peptide is studied across several areas of interest:
- Metabolic & energy-expenditure research: examined in models of energy balance and metabolism.
- GLP-1 receptor signaling: investigated for incretin-pathway activity in research models.
- GIP receptor signaling: studied alongside GLP-1 pathways in receptor-interaction research.
- Glucagon receptor signaling: explored for its role in the triple-agonist mechanism.
These describe areas of ongoing scientific investigation only, this compound is not a therapeutic product and no clinical outcomes are implied.
Specifications
| Compound |
Retatrutide (GLP-3 / LY3437943) |
| Class |
GIP / GLP-1 / glucagon triple receptor agonist (39 amino acids) |
| Molecular formula |
C221H342N46O68 |
| Molecular weight |
~4731.3 g/mol |
| CAS number |
2381089-83-2 |
| Form |
Lyophilized powder |
Reconstitution, Storage & Handling
Supplied as a lyophilized powder, the peptide is typically reconstituted with bacteriostatic or sterile water for laboratory use. Store the sealed lyophilized vial at -20 °C, protected from light and moisture, for long-term stability. After reconstitution, store at 2–8 °C and use within the timeframe defined by your laboratory protocol. Handle using standard laboratory safety practices.
For Research Use Only
This product is intended strictly for laboratory and in-vitro research. It is not for human or veterinary use, consumption, or diagnostic application and is not a drug, food, or cosmetic. By purchasing, the buyer affirms they are a qualified researcher or institution. Browse our full catalog of research peptides.
Further reading: Retatrutide research guide, what the studies show.
Retatrutide Certificate of Analysis (COA), Third-Party Lab-Tested
Every lot is independently tested by Freedom Diagnostics (USA). The lots below are verified at 99.76% to 99.91% HPLC-UV purity, with identity confirmed by LC-MS. Each lot has its own Certificate of Analysis.
| Size |
Lot |
Purity (HPLC-UV) |
Net content |
Reported |
Certificate |
| 10 mg |
590B4F2 |
99.76% |
10.95 mg |
21 Jun 2026 |
PDF |
| 10 mg |
RT10-2610 |
99.91% |
11.51 mg |
2 Nov 2026 |
PDF |
| 20 mg |
RT20-2610 |
99.91% |
23.97 mg |
2 Nov 2026 |
PDF |
Tracy Sabbarese (verified owner) –
Tara K. (verified owner) –
Amazing product, pure. Not only is the product great but the customer service team is amazing.